Description
Systemic autoimmune diseases such as SLE are characterized by the appearance of a variety of autoantibodies directed against cell components of the nucleus or plasma.
Although significance and pathological relevance of some autoantibodies are not completely revealed yet, the detection of autoantibodies is widely established and plays an important role in the diagnostics of systemic autoimmune diseases.
SLE has an unknown etiology and is characterized by multiorgan pathology. SLE has a female predominance. The onset of the disease occurs usually during childbearing age. Antibodies to dsDNA are the hallmark for SLE diagnostics and are included in the diagnostic criteria of the American College of Rheumatology for SLE